In combination with vemurafenib (PLX4032), a selective oral inhibitor of BRAF V600E associated with improved overall survival of patients with metastatic melanoma, vitamin C synergistically suppresses the proliferation and induces cell apoptosis and cycle arrest of BRAF-mutated TC cells, potentiating the effects of chemotherapy drug used as monotherapy [196,210]. Here, BRAF is linked to metastatic melanoma.