Within a bidirectional pathway, TERT upregulates Wnt/β-catenin pathway, whose impairment is related to many cancer and non-cancer diseases [73] and induces nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-dependent gene expression, such as interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-α)—namely, cytokines playing a crucial role in inflammation and cancer progression [72,74,75] (Table 2). The gene discussed is TNF; the disease is cancer.