TP53 and cancer: Mutation in the promoter of telomerase reverse transcriptase (TERT), which is associated with telomere length and risk of several cancers [33] and in the p53 tumor suppressor (TP53), a gene that has a crucial role in maintaining genetic stability and preventing cancer development [34], have been detected in the dedifferentiation process and, therefore, are generally linked to aggressive behaviors and poor prognosis [8,9].