DUOX1 and thyroid tumor: The same authors also reported that radio-induced thyroid tumors during childhood were characterized by significantly increased levels of DUOX1 gene expression compared with normal thyroid tissues, while in sporadic thyroid tumors, the increase in DUOX1 level was borderline significant, identifying DUOX1 as a major source of radio-induced oxidative stress and, as such, capable of promoting genomic instability and inducing TC [91,112].