In particular, myo-inositol modulated oral glucose tolerance tests (OGTTs) in polycystic ovary syndrome (PCOS) without familial diabetes, ALA increased insulin response to OGTT and metabolic parameters in all patients, and the combination of myo-inositol + ALA improved hormonal and metabolic aspects and insulin response to OGTT in all patients. Here, INS is linked to polycystic ovary syndrome.