It is important to determine whether lactobacillus inhibits senescence by decreasing DNMT1, m1A, m6A, TDP-43, GADD45, MMP-13, and ADAMTS1, and increasing TET2, 3MST, H2S and TIMPs in RED and Alzheimer’s disease. The gene discussed is GADD45A; the disease is early-onset autosomal dominant Alzheimer disease.