NFE2L2 and systemic lupus erythematosus: An analysis of the human Nrf2 gene structure in a small number of patients indicated that polymorphisms in the promoter and regulatory regions of the Nrf2 gene were not significantly associated with the risk of developing SLE [71]; however, the Nrf2-653 G/A polymorphism has been associated with the development of nephritis in childhood-onset female SLE patients [72].