NEIL1 and fibrosarcoma: From these, Neh1 and Neh2 are most important: Neh1 is a DNA-bending domain containing the CNC-bZIP region, in which the amino acid sequence is highly conserved throughout multiple species, playing a crucial role in mediating small musculoaponeurotic fibrosarcoma (sMaf), binding to antioxidant responsive element (ARE) and regulating transcription factor activity [24,25].