NFE2L2 and cataract: Various suppressors of Nrf2 can mimic features of cataracts in HLECs, such as apoptosis, endoplasmic reticulum stress and oxidative stress, while activators of Nrf2 have been shown to protect HLECs from features of cataract that are induced under treatment with homocysteine or hydrogen peroxide [125,132,133,134].