In addition, neuron-5 with upregulated Grm8, Adgrl2, and Tcf7 possibly played a role in neuroinflammation because Grm8 protects against neurodegeneration during CNS inflammation and oxidative stress [29], Adgrl2 is involved in the regulation of exocytosis, and Tcf7 is related to inflammation development and neural defenses against virus infection. Here, GRM8 is linked to viral infectious disease.