CAMK2D and Parkinson disease: Based on Gene Ontology analysis and comparison between the model and icaritin groups, the expression of several genes in PD-related pathways, including the succinate dehydrogenase complex iron sulfur subunit B (Sdhb) gene, NADH: ubiquinone oxidoreductase subunit A (Ndufa7 and Ndufa8), and calcium/calmodulin-dependent protein kinase II delta (Camk2d), were significantly altered in microglia (Figure S10D,E), indicating energy metabolism and oxidative stress-related pathways were strongly activated.