The 5xFAD mouse model of AD overexpresses mutant human amyloid precursor protein (APP) containing the Swedish (K670N, M67IL), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations, as well as the human presenilin 1 (PS1) gene with two FAD mutations, M146L and L286V. The gene discussed is PSEN1; the disease is familial Alzheimer disease.