STAT3 and osteosarcoma: Our group has demonstrated the biological activities of natural compounds in human osteosarcoma cells, including apoptosis and metastasis induced through the JAK2/STAT3 pathway after treatment with 4-parvifuran and 4-methyldalbergione isolated from Dalbergia odorifera, apoptosis effects from Hederoside C isolated from Pulsatilla koreana Nakai through the STAT3 signaling pathway, and autophagy and apoptosis effects from 11-O-Galloyl Bergenin isolated from Corylopsis coreanas through AKT inactivation and LC3II upregulation [42,43,44,45].