NFE2L2 and type 2 diabetes mellitus: Similarly, in type 2 diabetic (T2D) db/db mice, deletion of Nrf2 decreases the fasting blood glucose, renal hypertrophy, glomerular filtration rate, urinary albumin/creatinine ratio, tubular lipid droplet accumulation, and systolic blood pressure, via down-regulation of SGLT2, CD36, and FABP4 expression in proximal tubular cells [44].