Amyloid beta (Aβ) peptide and tau protein in AD, tau protein in primary tauopathies (including progressive supranuclear palsy [PSP]) and α-synuclein in PD and other synucleinopathies, are some of the main proteins implicated in this aggregative mechanism at the origin of the neurodegenerative processes. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.