In ALS, several protein aggregates are commonly found, including TDP-43, superoxide dismutase 1 (SOD1), fused in sarcoma (FUS), ataxin-2, optineurin, ubiquilin-2, and the translational product of chromosome 9 open reading frame 72 (C9ORF72). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.