In contrast, KIAA1429 knockdown induced significant cellular apoptosis in many cancer cells, including liver cancer [19,26], osteosarcoma [21], Ewing sarcoma [22], lung adenocarcinoma [23], diffuse large B-cell lymphoma [10], ovarian cancer [9], and chronic myeloid leukemia [25]. This evidence concerns the gene VIRMA and chronic myelogenous leukemia, BCR-ABL1 positive.