In fact, using nanomolar (nM) concentrations of siRNA specific to human VDAC1 across 30 cell lines has shown that VDAC1 silencing reduces membrane potential (ΔΨ), lowers cellular ATP levels, and inhibits cancer cell proliferation without affecting non-cancerous cells [19,75], This suggests that the absence of VDAC1 impacts mitochondrial energy conversion. Here, VDAC1 is linked to cancer.