Therefore, the purpose of this study was to preliminarily investigate the potential involvement of the muscle protein Cpt1b in the pathophysiology of osteoarthritis and osteoporosis by evaluating the expression and activity of the enzyme in the muscle tissue and myoblasts of healthy (CTR), osteoporotic (OP), and osteoarthritic (OA) subjects. This evidence concerns the gene CPT1B and osteoarthritis.