As mitochondrial function is essential for the redox balance [119], a study showed that mitochondrial dysfunction is associated with an increase in oxidative stress as shown by the higher level of ROS and MDA content, and low level of the activity of the antioxidants, GSH and SOD, in the LF from LSS patients as compared to the LF from a disc herniation control group [118]. Here, SOD1 is linked to Leigh syndrome.