In terms of molecular characteristics, TAMs from Slit-knockdown tumors showed a reduction in the expression of PD-L1 and PD-L2 inhibitors of T cell activation, increased expression of the cytotoxic genes IL-1b, IL-12, TNF-α, Ccr7, and Cxcl10 and reduced expression of the tumor-supportive genes TGF-β1, Mrc1, VEGF-a, Cd209a, MMP9, Arg1, Ccl19, and IL-10. This evidence concerns the gene MMP9 and neoplasm.