AQP7 and obesity due to melanocortin 4 receptor deficiency: In addition, the AP supplementation not only promoted AQP7 expression, but also reversed the hypomethylation status of the three CpG sites in the promoter of the AQP7 gene induced by the high-fat and high-sucrose diet, further emphasizing the significance of AQP7 in resisting diet-induced obesity [102].