Interestingly, similarly to the changing trend in AQP7 expression in subcutaneous adipose tissue in obesity, a significant decrease in the expression levels of multiple AQP7 isoforms such as the 37 kDa and 34 kDa isoforms of AQP7 was observed in the adipose tissues of T2DM patients with morbid obesity. This evidence concerns the gene AQP7 and obesity due to melanocortin 4 receptor deficiency.