Although studies have shown that there was a correlation between obesity and SNPs of the AQP7 gene only in female obesity [101], the levels of other substances related to the regulation of AQP7 expression were also changed in female obesity, such as an increasing trend in the expression levels of MCP1, TNF-α, and FSH [75] and a decreasing trend in PPARγ expression [100]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.