CHMP5 and COVID-19: With regard to the humoral response, we observed a strong presence of anti-Spike Abs anti-Wuhan nAbs in almost all patients, which correlated to the number of anti-SARS-CoV-2 vaccine doses received [132], according to the previous literature showing that vaccination against COVID-19 enhances immunity, leading to a significant rise in Spike antibody levels and enhanced neutralizing antibody responses in individuals with a history of mild COVID-19 [133].