In addition, targeting STING with its specific inhibitor C-176 decreases renal fibrosis in Pkd1 mutant mouse kidneys via a decrease of the expression of fibrotic markers, including TGF-β, α-SMA, collegen1, and fibronectin, resulting in a decrease of extracellular matrix deposition in Pkd1 mutant kidneys. The gene discussed is ACTA1; the disease is renal fibrosis.