Upon lactate treatment, an increase in the lactylation level of histones within NSCLC cells was noted, alongside the downregulation of transcripts for HK-1, G6PD, and pyruvate kinase (PKM), and the upregulation of succinate dehydrogenase (SDH), isocitrate dehydrogenase (IDH), and HIF-1α [49]. Here, G6PD is linked to non-small cell lung carcinoma.