Recent work has also identified TDP-43-mediated misspliced cryptic transcripts, such as STMN2, UNC13A, and HDGFL2 in AD and LATE [9, 12–14] suggesting that cryptic peptides as markers of TDP-43 dysfunction are relevant not only to ALS, FTD, AD, and LATE, but also to other neurodegenerative disorders with mixed pathologies such as Lewy body dementia, chronic traumatic encephalopathy, and other AD-related dementias. Here, HDGFL2 is linked to frontotemporal dementia.