More interestingly, after inhibiting Tregs with anti-CD25 and stimulating PD mice with rTMS, the levels of Syt6, TLR4, TH and Slc6a3 in PD mouse brains were significantly reversed compared with those in the PD + rTMS group (p < 0.0001; Fig. 3F, G). This evidence concerns the gene TLR4 and Parkinson disease.