Interestingly, MVA pathway blockade/deregulation has been linked to mitochondrial dysfunction with the consequent release of pro-apoptotic factors, defective autophagy, and possibly inflammasome activation with cell death (which occurs in the case of Mevalonate Kinase Deficiency MKD deficiency). The gene discussed is MVK; the disease is hyperinsulinemic hypoglycemia, familial, 4.