Given that the CMTM3-TLR4 axis may have a conserved survival benefit in biology (Branger et al, 2004), further studies should investigate the impact of CMTM3 on neutrophil egress and pathogen clearance in a CLP model without the use of antibiotics, to gain a more comprehensive understanding of the adaptive functions of this pathway and its role in sepsis pathophysiology. The gene discussed is TLR4; the disease is Sepsis.