CASP3 and non-small cell lung carcinoma: Functionally, the triple KD had stronger anti-tumorigenic effects compared to single or double KD in NSCLC cell lines, as shown by the reduced colony formation potential (Fig. 4C) and by the apoptotic phenotype demonstrated by Annexin V/PI staining and by cleaved casp3 (Fig. 4A, D, E, S5A, S12B).