PTEN and non-small cell lung carcinoma: Indeed, when YAP and TAZ were concomitantly depleted in two NSCLC cell lines, H1299 and H1975, a strong upregulation of PTEN was observed, concurrent with a decrease in CYCD1 (cyclin D1) transcript, a cell-cycle regulator that is negatively modulated by PTEN (Fig. 2A, B, S10A) [30].