Previous studies showed that YAP and EZH2 synergize to repress the transcription of lineage-specific genes and onco-suppressor genes in NSCLC, Schwann cells, trophoblast and intestine, and that YY1 (Yin Yang 1) transcription factor may bridge YAP and EZH2 at the promoter of cell-cycle regulators [17–20]. The gene discussed is YY1; the disease is non-small cell lung carcinoma.