SOX2 and neoplasm: Motif analysis implicated several known (AP-1 and SOX2) and novel (KLF and ETS) SCC-associated transcription factors with further refinement in vivo with a core set of TFs (AP-1 and ETS) across all tumor cells that coordinates with the more epithelial-specific KLF and SOX2 motifs (Yang et al. 2015).