Sphingosine phosphate lyase insufficiency syndrome (SPLIS), also known as NPHS14 or renal, endocrine, neurologic and immune (RENI) syndrome (OMIM # 617575)—is a rare autosomal recessive disorder first described in 2017 (Mitroi et al., 2017). The gene discussed is SGPL1; the disease is nephrotic syndrome 14.