Reports have indicated that RAG1/2‐mediated oncogenic splicing plays a critical role in leukemia cells, affecting genomic stability.[54] The E2F pathway, which is closely associated with genomic stability, is significantly impacted in T‐ALL cells upon disruption of IRF2BP2 expression, according to our RNA‐seq data. Here, IRF2BP2 is linked to acute lymphoblastic leukemia.