Studies have reported that IRF2BP2 inhibits IL‐1ß/TNFα signaling through NF‐κB, and disruption of IRF2BP2 leads to an acute inflammatory state, resulting in AML cell death.[43] Similarly, our RNA‐seq analysis showed that MYC and immune‐inflammatory pathways are significantly affected in T‐ALL cell lines with IRF2BP2 knockdown. Here, NFKB1 is linked to acute lymphoblastic leukemia.