Our previous research in esophageal adenocarcinoma identified E74 like ETS transcription factor 3 (ELF3), KLF transcription factor 5 (KLF5), GATA binding protein 6 (GATA6), and ETS homologous factor (EHF) as master TFs regulated by SEs, forming CRC that promotes tumor cell survival and proliferation.[19] In neuroblastoma, we identified several key oncogenes regulated by SEs driving tumor progression. This evidence concerns the gene KLF5 and colorectal carcinoma.