We then analyzed gene expression profiles of T‐ALL patients from the GEO dataset (GSE146901), which revealed a significant increase in IRF2BP2 mRNA expression in T‐ALL patient samples compared to normal T cells (Figure 1C; Figure S5B, Supporting Information), and significant increase in IRF2BP2 protein levels in T‐ALL cell lines compared to normal T cells (Figure S6A, Supporting Information). Here, IRF2BP2 is linked to acute lymphoblastic leukemia.