The Notch‐Myc signaling axis, along with transcription factors (TFs) LYL1, basic helix‐loop‐helix family member (LYL1), LMO1/2, TLX1/3, NKX2‐1, and TAL1/2, collaboratively regulate the expression of genes involved in T cell development such as the RAG family members recombination activating 1 (RAG1) and recombination activating 2 (RAG2).[4, 5, 6] Genetic abnormalities in these factors have been reported to be linked to the occurrence of pediatric T‐ALL. Here, LYL1 is linked to acute lymphoblastic leukemia.