Among these genes, CDK6, ELF1, SPTBN1, and MSI2 have been confirmed to be crucial in regulating T‐ALL progression.[23, 24, 25, 26] Visualization of the ChIP‐seq data indicated significant enrichment of H3K27ac downstream of the IRF2BP2 gene in T‐ALL patients and cell lines, whereas these H3K27ac peaks were notably weaker or absent in CD3+T, CD4+T, and CD8+T cells (Figure 1B). This evidence concerns the gene CD8A and acute lymphoblastic leukemia.