To further elucidate the mechanism underlying NF-κB-TERT feedback regulation on apoptosis of ovarian granulosa cells in PCOS rats, we treated LPS-induced KGN cells with 10μg/ml BAY 11–7082 and 40 μg/ml BIBR1532, respectively. This evidence concerns the gene NFKB1 and polycystic ovary syndrome.