In addition, the associations of periodontitis status and CRP levels with mortality were also found to be significant in the multivariate model including all confounders, with HRs of 1.29 (95% CI, 1.03–1.61) and 1.44 (95% CI, 1.16–1.78) for periodontitis status and CRP level, respectively (S1 Table). The gene discussed is CRP; the disease is periodontitis.