Similarly, M1 patients from both cohorts demonstrated similar pre-PBx ages and PSA, whereas nonmetastatic PCa patients at our center were older (median: 70 vs. 66 years, P<0.001) and had higher PSA levels (median: 12.34 vs. 5.9 ng/ml, P<0.001) (Fig. 1G,H). Here, KLK3 is linked to posterior cortical atrophy.