Using the prespecified cut-off of CgA change for tumor progression, specificity was 93.4% (95% confidence interval, 90.4%–95.5%; P < 0.001), sensitivity 34.4% (25.6%–44.3%), positive predictive value 57.9% (45.0–69.8), negative predictive value 84.3% (80.5–87.6), and AUC 0.73 (0.67–0.79). The gene discussed is CGA; the disease is neoplasm.