In addition, in relevant animal models, in the human retina with diabetic retinopathy or with wet AMD,13,22 as well as in a model of retinopathy of prematurity,23 MR expression is increased and MR antagonism reduced retinal inflammation and activation of retinal microglial cells24 demonstrating the proinflammatory role of MR activation in the retina. Here, NR3C2 is linked to wet macular degeneration.