Because MR is mostly occupied by GCs in the retina and MR is overexpressed in pathological conditions like diabetes or aging, but also that aldosterone and GCs may not regulate the same genes when they activate MR, transgenic models in which MR is overexpressed could reflect more accurately the effect of MR overactivation in the development of non-primarily inflammatory retinal diseases. The gene discussed is NR3C2; the disease is diabetes mellitus.