Thus, it is possible that heterozygosity for the Alk1 deletion in ECs may result in reduced expression of STAB2, and the expression of Cre recombinase driven by the Stab2 promoter accordingly decreases, so that the Alk1-floxed allele in ECs cannot be efficiently deleted by Cre-mediated cyclization, which may explain why liver fibrosis did not occur in Alk1fl/flStab2Cre mice. This evidence concerns the gene ACVRL1 and Hepatic fibrosis.