Notably, the chemokine C‐X3‐C‐motif ligand‐chemokine C‐X3‐C‐motif receptor 1 (CX3CL1‐CX3CR1) axis up‐regulation is consistently associated with spanning ischemia, AD, PD, and HD, implying its crucial role in the neurodegenerative processes (Subbarayan et al., 2022). This evidence concerns the gene CX3CR1 and Alzheimer disease.