CX3CL1 and Alzheimer disease: Notably, the chemokine C‐X3‐C‐motif ligand‐chemokine C‐X3‐C‐motif receptor 1 (CX3CL1‐CX3CR1) axis up‐regulation is consistently associated with spanning ischemia, AD, PD, and HD, implying its crucial role in the neurodegenerative processes (Subbarayan et al., 2022).