Bodyweight gain: TCS ↑ (PND5, PND30, PND60: 8)Visceral fat-to-bodyweight ratio and adipocyte size: TCS ↑ (PND30: 8)Fasting plasma glucose and serum insulin level: TCS ↑ (PND60)Areas under the curve of glucose and insulin tolerance test: TCS ↑ (PND60)The phenotype of insulin resistance and hyperphagic obesity: TCS ↑Cumulated food intake within 4 days: TCS ↑ (PND30)Food intakes normalized by bodyweight: TCS ↑ (PND30)Oxygen consumption: no effect. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.