Indeed, both studies found a greater number of microvascular alterations in scleroderma patients compared to healthy controls, supporting the previous hypothesis of microvascular damage in sarcoidosis [19,21], where in fact the activation of the angiogenic pathway and an imbalance between angiogenesis and angiostasis involving VEGF have already been described [47,48,49]. The gene discussed is VEGFA; the disease is scleroderma.