Circulating levels of FGF21 are increased in subjects with obesity [14], dyslipidemia [15], metabolic syndrome [14], diabetes mellitus [16], nonalcoholic fatty liver disease, coronary artery disease [17], atherosclerosis [18], acute myocardial infarction [19], diabetic nephropathy [20], and arterial hypertension [21]. The gene discussed is FGF21; the disease is diabetes mellitus.