Data from The Cancer Genome Atlas for RCC identified multiple mutations in patients with ccRCC, including the VHL, PBRM1, SETD2, KDM5C, PTEN, BAP1, MTOR, and TP53 genes, thereby emphasizing the anticipated metabolomic heterogeneity in ccRCC [90]. This evidence concerns the gene TP53 and nonpapillary renal cell carcinoma.