Data from The Cancer Genome Atlas for RCC identified multiple mutations in patients with ccRCC, including the VHL, PBRM1, SETD2, KDM5C, PTEN, BAP1, MTOR, and TP53 genes, thereby emphasizing the anticipated metabolomic heterogeneity in ccRCC [90]. The gene discussed is PBRM1; the disease is renal cell carcinoma.