Data from The Cancer Genome Atlas for RCC identified multiple mutations in patients with ccRCC, including the VHL, PBRM1, SETD2, KDM5C, PTEN, BAP1, MTOR, and TP53 genes, thereby emphasizing the anticipated metabolomic heterogeneity in ccRCC [90]. The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.