Our previous human findings indicated that BC supplementation for six months reduced the loss of whole-body BMD and significantly increased the concentration of serum amino-terminal propeptide of type 1 procollagen (P1NP), a biomarker of bone formation [26], while marginally significantly decreasing the receptor activator of nuclear factor kappa-Β ligand (RANKL, only in the high BC group) (p = 0.052) [27]. Here, TNFSF11 is linked to breast cancer.