Given that Akkermansia plays a role in stimulating GLP-1 secretion [54], and that RPS was previously shown in a Western diet T2D swine model to elevate GLP-1 levels, decrease fasting blood glucose, and attenuate insulin resistance [55], we may speculate that reduced FFA levels are a consequence of enhanced insulin signaling due to elevated GLP-1, which might be driven by an enrichment of Akkermansia in those consuming RPS. The gene discussed is INS; the disease is Insulin resistance.