In addition, AST downregulated the expression of Ki67, reduced the malignant proliferation of colon cancer cells, and inhibited the expression of the proinflammatory factors IL-6, IL-1β, and tumor necrosis factor-α, thereby attenuating the colitis-associated colon cancer injury induced by AOM/DSS in mice. The gene discussed is TNF; the disease is malignant colon neoplasm.