CYP19A1 and neoplasm: It is worth noting that, in addition to cytotoxic activity against tumor cells, the potential of some diterpenes as antitumor active molecules is reflected in their inhibitory activity against specific target proteins like Cbl-b, aromatase, etc. The production of cytotoxic metabolites by sponges may be beneficial for their self-protection, such as against predators and spatial competition [28].