Although all these circRNAs are ecircRNAs, they show different regulation mechanisms on the parental genes by interacting with nucleic acid molecules: hsa_circ_0002320 has the ability to bind directly with its parental mRNA and inhibit its translation in BC [15]; and hsa_circ_0024097 [72] and circLECRC [80] act as ceRNAs to enhance or inhibit YAP1 expression in osteoporosis and CRC. This evidence concerns the gene YAP1 and colorectal carcinoma.