Analogously, An et al. [80] showed that circLECRC (hsa_circ_0004140) blocks the advancement of CRC by regulating the circLECRC/miR-135b-5p/KLF4 pathway to prevent the excessive activation of cancer-causing YAP1 signaling in CRC. The gene discussed is KLF4; the disease is colorectal carcinoma.