Older age, male gender, risky occupations, fever, headache, muscle ache, dyspnea, diarrhea, diabetes mellitus, heart disease, bronchial asthma, lower platelets, low absolute lymphocytic count, higher NLR, PLR, CRP, transferrin, LDH, and D dimer were associated with more-severe COVID-19. The gene discussed is CRP; the disease is diabetes mellitus.