Higher levels of IgG antibody responses to HP0305, CagA and Catalase were associated with polyp development (OR = 2.65, 95% CI: 1.31–5.36, OR = 1.83, 95% CI: 1.01–3.32, and OR = 2.16, CI: 1.09–4.29, respectively, Table 3), while the IgG response to HpaA was associated with advanced adenoma occurrence (OR = 2.46, 95% CI: 1.00–6.01, Table 3). Here, S100A8 is linked to polyp.