We previously showed that IgG and IgA seropositivity to F. nucleatum proteins was associated with CRC and that, conversely, seropositivity to SGG was associated with an increased risk for precancerous lesions, leading to the hypothesis that the first bacterium might act as a “passenger bacterium” increasing in abundance due to favourable growth conditions with dysplastic progression, while SGG may be a potential aetiological factor in the transition of a polyp to malignant disease, and its detection could help to identify precursors that may more likely progress to cancer [5]. The gene discussed is CD79A; the disease is colorectal carcinoma.