Additionally, the study explored the ET-1/endothelin receptor type A (ETAR) axis, finding that inhibiting the ERK1/2 pathway downregulated ET-1 and FOX01, suggesting ET-1’s role in promoting cell proliferation, migration, and anti-apoptosis in gastric cancer through the ET-1/ETAR axis [56]. The gene discussed is EDN1; the disease is gastric cancer.