Smurf1−/− BMDMs secreted similar levels of IL-6 compared to MHV-A59-infected wild-type in all periods evaluated, with the exception of 48 h post-infection, when IL-6 secretion by Smurf1−/− BMDMs was lower, compared to wild-type infected cells (Figure 1b). The gene discussed is SMURF1; the disease is infection.