HSP70 and HSP60 are also essential for appropriate erythropoietic responses by aiding in protein folding, protecting erythroid precursors from stress-induced apoptosis during hypoxia and iron deficiency, supporting mitochondrial function, and regulating the differentiation and proliferation of the erythroid lineage [90,91,92]. The gene discussed is HSPA14; the disease is Iron deficiency anemia.