This analysis confirmed significant dysregulation of DEGs in the HSP60-HSP70-TLR2/4 signaling pathway (54/54 nodes, Padj = 9.041 × 10−13, Figure S1), confirming that dysregulation in the signaling pathway is a general feature of SMA in children with and without sickle cell anemia. This evidence concerns the gene TLR2 and sickle cell disease.