To mitigate any potential confounding effects of HbSS carriage on our findings related to immune dysregulation in the HSP60-HSP70-TLR2/4 signaling pathway, canonical pathway mapping was performed in children without SCA in the non-SMA (n = 39) and SMA (n = 18) groups. Here, HSPA4 is linked to autosomal dominant cerebellar ataxia.