Moreover, HSP70 may play a role in the severe anemia witnessed in individuals with β-Thalassemia (β-TM) since HSP70 directly interacts with free αglobin chains in human β-TM erythroblasts, resulting in HSP70 sequestration in the cytoplasm, a process that promotes GATA-1 degradation [89]. This evidence concerns the gene HSPA4 and anemia (phenotype).