A large body of research indicates the role of Fh-ES-derived molecules in suppressing inflammation in experimental models of autoimmune diseases: Fh-HDM-1 may ameliorate symptoms of type I diabetes or multiple sclerosis [60], GST attenuates septic shock in mice [41,61] whereas purified EVs are beneficial during ulcerative colitis [62]. Here, FH is linked to multiple sclerosis.